| Acronym | Definition |
| DIG | Data Item Group (US DoD) |
| DIG | Dead in Ground |
| DIG | Departement Informatique de Gestion |
| DIG | Department Inspection Group |
| DIG | Deputy Inspector General |
| DIG | Detergent-Insoluble Glycolipid-Enriched Domain (cell & molecular biology) |
| DIG | Detonator Inspection Gauge |
| DIG | Developers Interface Guide |
| DIG | Digest |
| DIG | Digiorgio Corporation (NYSE Symbol) |
| DIG | Digital |
| DIG | Digital Image Generator |
| DIG | Digital Imaging Group |
| DIG | Digital Information Group |
| DIG | Digoxigenin (DNA marker) |
| DIG | Direct Inertial Guidance |
| DIG | Disaster Information Gateway |
| DIG | Discussion Group(s) |
| DIG | Discussion in Groups |
| DIG | Dismissed as Improperly Granted (legal) |
| DIG | Disney's Internet Guide |
| DIG | Distributed Information Gathering |
| DIG | DOE Interaction Group |
| DIG | Domain Information Groper |
| DIG | Domain Internet Groper |
| DIG | Drop in Game (informal ice hockey) |
| DIG | Developer'S Interest Group |
| DIG | Digitizer |
